SCIENCE SERVICES

At Alderley Park you will have access to a range of valuable centralised scientific services in support of your research, all available on a pay as you go basis.

WATERS LAB

CYTIVA TECHNOLOGY LAB

SUPPORTING SCIENTIFIC SERVICES

THERMO FISHER SUPPLY CENTRE

NMR LAB

INVIVO FACILITIES

PRE CLINICAL IMAGING

GLASS WASH

WATERS LAB

Operated in partnership with Waters Corporation and fully supported by an experienced team, analytical and preparative scale LCMS instrumentation are available for walk-up sample submission or session based bookings.

  • Two Acquity H-Class UPLC systems equipped with QDa single quadrupole mass detectors run continuously, providing industry leading levels of resolution, sensitivity, and throughput across a diverse range of sample types. Find out more

  • Fraction Lynx Autoprep platform for mass directed reverse phase purification of starting materials, intermediates and final products, serving researchers in the pharmaceutical, food, agrochemical, FMCG and related industries. Find out more

N.B Different pieces of equipment can also be added upon if demand merits the addition of equipment

CYTIVA TECHNOLOGY LAB

Showcasing the latest in cell and protein analysis technologies, with onsite support from Cytiva, the Cytiva Technology Lab is continually updated to provide researchers with a powerful suite of high-end research tools.

  • Surface Plasmon Resonance (SPR): Biacore 8k is a high-throughput, high-sensitivity SPR system that enables efficient screening characterization, process optimisation, and quality control of small molecules and biotherapeutics. Find out more

  • Biomolecular Imaging: Amersham ImageQuant 800 - The Amersham ImageQuant 800 systems, with Fujifilm optics and the SNOW imaging mode, allow you to stretch the dynamic range and easily image low and high abundance proteins. Find out more

  • Protein Purification: ÄKTA Pure and ÄKTA Avant - The ÄKTA pure chromatography system allows for quick and easy customisation thanks to the modular design of both the hardware and software. Find out more

  • Tangential Flow Cell Filtration: ÄKTA Flux S - The ÄKTA flux is a semi-automated tangential flow filtration/cross flow filtration system for concentration and diafiltration as well as cell harvest and clarification. Find out more

N.B Different pieces of equipment can also be added upon if demand merits the addition of equipment

SUPPORTING SCIENTIFIC SERVICES

We work with industry-leading service providers to support your research by providing a comprehensive range of specialist on-site services.

  • Waste disposal (clinical, solvent, chemical)
  • Cryogens, ice and dry ice
  • Cold storage (4°C, -20°C, -80°C)
  • Scientific logistics and sample shipping
  • Equipment maintenance
  • Lab coat laundry

THERMO FISHER SUPPLY CENTER

The Supply Center is designed to provide a customizable mix of products on site for immediate access.

A Supply Center is similar to a digitised vending machine, which has the ability to store products at the proper temperature and allows users to quickly obtain a comprehensive range of lab consumables while doing your research.

On top of the flexibility of instant fulfilment and automated restocking, Supply Center can also help support your lab’s sustainability efforts:

  • By consolidating restocking shipments, Thermo Fisher Scientific and its customers together reduce packaging waste by ~317,500 kg annually
  • Through your Supply Center, you can choose from more than 1,400 greener product alternatives available for purchase in the product catalog—simply look for the green leaf symbol

NMR LAB

Alderley Park researchers benefit from 24/7 access to high end NMR instrumentation.

  • 500MHz Avance III HD spectrometer with double resonance broad banded SmartProbe
  • Always available for walk up sample submission, providing rapid turnaround and timely access to analytical information
  • A menu of predetermined 1D and 2D experiments is available, with new experiments added on request

INVIVO FACILITIES

A 10,500 sq ft facility offering dedicated space and communal access to a range of rooms and specialised suites, and that benefits from the following:

  • 6000 IVC rodent cage capacity
  • Housing, husbandry and procedural support for all rodent species
  • In-vivo surgery suite and surgical support
  • Procedural suites
  • Level 2 containment area
  • Bio-imaging suite
  • Fume cupboard

PRE CLINICAL IMAGING

At Alderley Park you have access to Medicines Discovery Catapult’s world-class capabilities and expertise in in vivo bioimaging and ex vivo bioanalysis of tissues. They have an experienced team with specialist technical expertise and extensive drug discovery know-how.

Their imaging platforms can be used to visualise in cells, tissues and rodents the biodistribution of molecules, track novel drug delivery and complex medicine modalities, and provide clear evidence of biomarker responses to novel drug candidates. Medicines Discovery Catapult can access specialist in vivo models and PET radiotracers to meet specific programme needs.

They provide imaging to enable quantification of:

  • Drug Biodistribution and Organ accumulation in Rodents * PET distribution of radiotracer - e.g. 89Zr Radiolabelled distribution candidate - Distribution and accumulation of compound over time * Near Infra-Red and micro-CT bioimaging - Deep whole-body penetration and biodistribution * Bioluminescence imaging - Ability to perform lentiviral transduction of luciferase expressing cell lines and then image these within animal model

  • Tissue Imaging of Pathway Changes and Drug Localisation * Mass Spectrometry Imaging - a High-content, approach that can provide targeted or untargeted molecular localisation and biomarker information on many molecules. Amenable to analysis of any flat surface (e.g. skin sections, organoid sections). MDC - DESI Mass Spectrometry Imaging and MALDI-Mass Spectrometry imaging, as well as omics measurement through high throughput mass spectrometry techniques. * Tissue pathology imaging capabilities using high resolution platforms to track molecular signalling * A suite of high resolution, confocal and super-resolution imaging platforms enables ex vivo tissue studies- for example building on top of the preclinical near infra-red imaging in animals with detailed tissue images

  • Biomarker Studies * Preclinical use of a range of radiotracers such as 18F-FDG PET; 18F-FAZA PET and others * Spatial transcriptomic studies on molecular changes within multiple tissue subregions using Nanostring GeoMx that enables detailed understanding of drug responses with high spatial resolution

GLASS WASH

The on-site Glass Wash team is able is able to support your research by disinfecting and sterilising glassware from our recently refurbished glass wash and sterilisation facility, based in No. 21.

The facility is equipped with: :

  • 2 x Getinge Lancer 1400LX industrial lab Glass Washers capable of * Hot or Cold wash cycles to suit your demands * Acid and Alkaline washes to remove biofilms, proteins, nucleic acids and chemical residues * Optional De-ionised water rinse * Dried with hot air (60-115°C)
  • 2 X LTE Scientific 120L Touchclave R Steam autoclaves Steam autoclaves are considered the gold standard for sterilisation and utilise high temperature pressurised steam to sterilise a variety of glassware, labware and with liquids (buffers, media, water). This high temperature and pressure causes hydrolysis and coagulation of protein - killing bacteria, microbes, spores, and viruses leaving autoclave products sterile and ready for any application. Steam sterilisation typically involves exposing an item to steam at a temperature of 121°C for 10-15 minutes.